Skull-base surgery is a specialized form of neurosurgery that focuses on the complex area where the skull and spine meet. This region is critical because it houses vital structures, including the brainstem, cranial nerves, and major blood vessels. Skull-base surgery is often required to address conditions such as tumors, vascular malformations, or congenital abnormalities in this challenging anatomical area. The procedure typically involves intricate techniques to navigate around sensitive structures, often using endoscopic or minimally invasive approaches to minimize damage and enhance recovery. Multidisciplinary teams, including neurosurgeons, ENT specialists, and oncologists, collaborate to provide comprehensive care and achieve optimal outcomes. Advances in imaging and surgical techniques have made skull-base surgery safer and more effective, improving the quality of life for many patients.